Journal article
Alterations in brain transition metals in Huntington disease: An evolving and intricate story
HD Rosas, YI Chen, G Doros, DH Salat, NK Chen, KK Kwong, A Bush, J Fox, SM Hersch
Archives of Neurology | Published : 2012
Abstract
Background: Aberrant accumulation of transition metals in the brain may have an early and important role in the pathogenesis of several neurodegenerative disorders, including Huntington disease (HD). Objective: To comprehensively evaluate and validate the distribution of metal deposition in the brain using advanced magnetic resonance imaging methods from the premanifest through symptomatic stages of HD. Design: Observational study. Setting: University imaging center. Participants: Twenty-eight HD expanded gene carriers, 34 patients with symptomatic HD, and 56 age- and sex-matched healthy control subjects were included in the study. Interventions: Participants underwent magnetic resonance ima..
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Grants
Awarded by National Center for Complementary and Integrative Health
Funding Acknowledgements
This research was supported in part by the National Institutes of Health, including the following grants: R01NS042861 and NS058793 from the National Institute for Neurological Disorders and Stroke (Drs Rosas, Y. I. Chen, Doros, Salat, and Hersch), AT000613 (Drs Rosas, Y. I. Chen, and Hersch) and P01AT002048 from the National Institute of Biomedical Imaging and Bioengineering (Dr Kwong), R21EB005690 from the National Center for Complementary and Alternative Medicine (Dr N.-k. Chen), HDSA Coalition for the CURE (Dr Fox), FD003359 from the Food and Drug Administration (Drs Rosas, Y. I. Chen, and Hersch), SFCA07-101 from the International Foundation for Gastrointestinal Disorders, NR010827 from the National Institute of Nursing Research (Dr Salat), and National Health and Medical Research Council (Dr Bush).